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N Engl J Med 1980; 303:922-926 DOI: 10.1056/NEJM198010163031607

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Jan Koch-Weser, M.D., Editor

This article has no abstract; the first 100 words appear below.

MINOXIDIL (Loniten), a piperidino-pyrimidine derivative (Fig. 1), is an unusually potent vasodilator of unique value in treating patients with severe hypertension. After 11 years of clinical investigations, it was approved by the Food and Drug Administration in October 1979 for treatment of patients who cannot tolerate or respond to a conventional three-drug antihypertensive regimen. Initially, trials were limited to such patients because of experiments that showed a right atrial hemorrhagic lesion in dogs, which proved to be specific to this species. Trials of efficacy and safety are currently under way in less severely hypertensive patients but have not as yet ...

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Supported by a grant (HL 23670–01) from the National Institutes of Health.

I am indebted to Drs. Helen Mitchell and Robert Graham for review of the manuscript and to Ms. Cathy Johns and Clara Ying for secretarial assistance.

From the Division of Clinical Pharmacology, Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, TX 75235, where reprint requests should be addressed to Dr. Pettinger.

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N Engl J Med 1980; 303:922-926 DOI: 10.1056/NEJM198010163031607

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Jan Koch-Weser, M.D., Editor

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Venezuela

Marcos Carbono (center) joins a protest against the weekend's election in Venezuela in front of that country's consulate in Miami. President Nicolás Maduro may have won the vote count but in the process lost the legitimacy to govern, one expert writes.

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Venezuela's latest vote will worsen its crisis as it consolidates its socialist authoritarian system. But Washington is not well-positioned to lead the charge to stop it, writes Ted Piccone.

Opponents of Venezuelan President Nicolas Maduro protest the presidential election which Maduro won, in Caracas, Venezuela, on Monday.

The Two-Way

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Venezuela's President Nicolás Maduro and his wife, Cilia Flores, wave to supporters at the presidential palace in Caracas on Sunday after election officials declared his victory.

The Two-Way

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Venezuela's President Nicolás Maduro greets supporters during a closing campaign rally in Caracas, Venezuela, Thursday. Maduro is seeking a new six-year mandate.

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Deep economic crisis and distrust of the government seem to have corroded many Venezuelans' faith in politics. Main opposition parties are even boycotting Sunday's vote.

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Laurie Holt holds a photograph of her son, Joshua Holt, at her home, in Riverton, Utah. Holt, who has been held in a Venezuelan jail for two years, uploaded a video plea for his released to Facebook this week.

The Two-Way

Earlier this week, 26-year-old Joshua Holt, who has been jailed in the South American country since 2016, uploaded a video to Facebook expressing fear that fellow inmates were trying to kill him.

Venezuelan opposition presidential candidate Henri Falcón addresses reporters in Caracas on May 8.

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